1. Encounter: Kitra returns! - ECCIE Worldwide
Default Encounter: Kitra returns! User ID: - Date: First week of March Name: Kitra Somers Phone: 5176040048. Email Address: KitraSomers@gmail.com. URL ...
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CyberCTM - https://telegra.ph/Kitra-Somers-Therapist-on-Twitter-whos-hitting-the-gym-Amanda-Greenes-Instagram-Twitter-Facebook-on-IDCrawl-01-14.
CyberCTM - https://telegra.ph/Kitra-Somers-Therapist-on-Twitter-whos-hitting-the-gym-Amanda-Greenes-Instagram-Twitter-Facebook-on-IDCrawl-01-14
3. Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra ...
1 nov 2019 · & Somers, G. R. The CIC-DUX4 fusion transcript is present in a subgroup of pediatric primitive round cell sarcomas. Hum. pathol. 43, 180–189 ...
Approximately 60–70% of EWSR1-negative small blue round cell sarcomas harbour a rearrangement of CIC, most commonly CIC-DUX4. CIC-DUX4 sarcoma (CDS) is an aggressive and often fatal high-grade sarcoma appearing predominantly in children and young adults. Although cell lines and their xenograft models are essential tools for basic research and development of antitumour drugs, few cell lines currently exist for CDS. We successfully established a novel human CDS cell line designated Kitra-SRS and developed orthotopic tumour xenografts in nude mice. The CIC-DUX4 fusion gene in Kitra-SRS cells was generated by t(12;19) complex chromosomal rearrangements with an insertion of a chromosome segment including a DUX4 pseudogene component. Kitra-SRS xenografts were histologically similar to the original tumour and exhibited metastatic potential to the lungs. Kitra-SRS cells displayed autocrine activation of the insulin-like growth factor 1 (IGF-1)/IGF-1 receptor (IGF-1R) pathway. Accordingly, treatment with the IGF-1R inhibitor, linsitinib, attenuated Kitra-SRS cell growth and IGF-1-induced activation of IGF-1R/AKT signalling both in vitro and in vivo. Furthermore, upon screening 1134 FDA-approved drugs, the responses of Kitra-SRS cells to anticancer drugs appeared to reflect those of the primary tumour. Our model will be a useful modality for investigating the molecular pathology and therapy of CDS.
4. Inactivation of the CIC-DUX4 oncogene through P300/CBP ...
12 okt 2021 · To test this hypothesis, we knocked down P300 and CBP in two cell lines, NCC-CDS-X1 and Kitra-SRS, derived from independent CDS tumors [27 ...
CIC-DUX4 sarcoma (CDS) is a highly aggressive and metastatic small round type of predominantly pediatric sarcoma driven by a fusion oncoprotein comprising the transcriptional repressor Capicua (CIC) fused to the C-terminal transcriptional activation domain of DUX4. CDS rapidly develops resistance to chemotherapy, thus novel specific therapies are greatly needed. We demonstrate that CIC-DUX4 requires P300/CBP to induce histone H3 acetylation, activate its targets, and drive oncogenesis. We describe the synthetic route to a selective and highly potent P300/CBP inhibitor named iP300w and related stereoisomers, and find that iP300w efficiently suppresses CIC-DUX4 transcriptional activity and reverses CIC-DUX4 induced acetylation. iP300w is active at 100-fold lower concentrations than related stereoisomers or A-485. At low doses, iP300w shows specificity to CDS cancer cell lines, rapidly inducing cell cycle arrest and preventing growth of established CDS xenograft tumors when delivered in vivo. The effectiveness of iP300w to inactivate CIC-DUX4 highlights a promising therapeutic opportunity for CDS.
5. Top 12 John Somers Quotes - Quotestats.com
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7. Kitra Somers Therapist on Twitter Part 2 is the front view ❤️ - Telegraph
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